Batteryless Device Detects Covid Droplets In the Air Around You

Researchers have developed a unique batteryless and wireless device that can detect within no time coronavirus in the air, if your surroundings contain Covid-19 particles or droplets the moment they enter the vicinity.

The device, which requires no batteries, employs a magnetostrictive clad plate composed of iron, cobalt and nickel, generating power via alternative magnetisation caused by vibration.

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Wireless Implant Could Help Remove Deadly Brain Tumors

Brain tumors are among the most deadly and difficult-to-treat cancers. Glioblastoma, a particularly aggressive form, kills more than 10,000 Americans a year and has a median survival time of less than 15 months. For patients with brain tumors, treatment typically includes open-skull surgery to remove as much of the tumor as possible followed by chemotherapy or radiation, which come with serious side effects and numerous hospital visits.

What if a patient’s brain tumor could be treated painlessly, without anesthesia, in the comfort of their home? Researchers at Stanford Medicine have developed, and tested in mice, a small wireless device that one day could do just that. The device is a remotely activated implant that can heat up nanoparticles injected into the tumor, gradually killing cancerous cells. In mice with brain tumors, 15 minutes of daily treatment over 15 days, as the animals went about their normal activities, was enough to significantly increase survival times. The researchers published their work in August in Nature Nanotechnology.

The nanoparticles help us target the treatment to only the tumor, so the side effects will be relatively less compared with chemotherapy and radiation,” said Hamed Arami, PhD, co-lead  author of the paper, a former postdoctoral fellow at Stanford Medicine who is now at Arizona State University.

Arami, trained as a bioengineer, came to focus on brain cancer as a postdoctoral fellow in the lab of the late Sam Gambhir, MD, former chair of radiology at Stanford Medicine and a pioneer in molecular imaging and cancer diagnostics who died of cancer in 2020 . Five years prior, Gambhir’s teenage son, Milan, died of a glioblastoma.

Source: https://scopeblog.stanford.edu/

Smart Contact Lens to Treat Glaucoma

A flexible contact lens that senses eye pressure and releases a drug on-demand could help treat glaucoma, the second leading global cause of blindness worldwide. The compact wireless device, which has been developed by a team of Chinese researchers and tested in pig and rabbit eyes so far, appears to detect and reduce rising eye pressure, one of the usual causes of glaucoma.

Glaucoma is an umbrella term for a group of eye diseases where damage to the optic nerve, which relays visual information to the brain, causes irreversible vision loss and blindness in millions of people worldwide. Where this new research makes ground is in developing a device capable of detecting changes in eye pressure and delivering therapeutic drugs as needed. Recent efforts to develop smart contact lenses as wearable devices for treating eye conditions have either focused on sensing pressure changes in the eye or delivering a drug – but not both – and glaucoma treatment usually involves eye drops, laser therapy, or surgery to reduce eye pressure. While it sounds exciting, keep in mind that as scientists continue experimenting with all sorts of nifty devices for treating eye diseases, early detection of glaucoma and timely treatment remains vital.

Once detected, therapy for glaucoma can arrest or slow its deterioration in the majority of cases,” Jaimie Steinmetz, a research scientist at the Washington-based Institute for Health Metrics and Evaluation, and collaborators wrote in 2020 when analyzing the global burden of eye diseases, including glaucoma. But glaucoma is typically hard to catch because peripheral vision is the first to go, and devices used to diagnose the condition only provide snapshot measurements of intraocular pressure, which fluctuates with activity and sleep-wake cycles.

Hence the importance of improving systems of surveillance, highlighting risk among family members of cases, and effectiveness of care once treatment is initiated,” Steinmetz and co-authors stressThat said, contact lenses which sit snug against the eye hold great appeal for delivering therapies for eye conditions. But incorporating electrical circuits and sensors into small, flexible, curved, and ultra-thin contact lenses presents a serious engineering challenge. For something like this to work, it needs to be sensitive enough to detect pressure changes and release precise amounts of drug on demand – all without blocking vision and irritating the eye. “It is highly challenging to install an intricate theranostic system composited by multi-modules on a contact lens,” electrical engineer Cheng Yang of Sun Yat-Sen University and colleagues write in their paper.

Manipulating The “Boss Gene” For Reprogramming Humans

 

It seems like everything is going wireless these days. That now includes efforts to reprogram the human genome. A new University at Buffalo-led study describes how researchers wirelessly controlled FGFR1 — a gene that plays a key role in how humans grow from embryos to adults — in lab-grown brain tissue. The ability to manipulate the gene, the study’s authors say, could lead to new cancer treatments, and ways to prevent and treat mental disorders such as schizophrenia.

It represents a step forward toward genetic manipulation technology that could upend the treatment of cancer, as well as the prevention and treatment of schizophrenia and other neurological illnesses. It centers on the creation of a new subfield of research the study’s authors are calling “optogenomics,” or controlling the human genome through laser light and nanotechnology.

The left image shows the gene FGFR1 in its natural state. The right image shows the gene when exposed to laser light, which causes the gene to activiate and deactivate.

The potential of optogenomic interfaces is enormous,” says co-author Josep M. Jornet, PhD, associate professor in the Department of Electrical Engineering in the UB School of Engineering and Applied Sciences. “It could drastically reduce the need for medicinal drugs and other therapies for certain illnesses. It could also change how humans interact with machines.

For the past 20 years, scientists have been combining optics and genetics — the field of optogenetics — with a goal of employing light to control how cells interact with each other. By doing this, one could potentially develop new treatments for diseases by correcting the miscommunications that occur between cells. While promising, this research does not directly address malfunctions in genetic blueprints that guide human growth and underlie many diseases. The new research begins to tackle this issue because FGFR1 — it stands for Fibroblast Growth Factor Receptor 1 — holds sway over roughly 4,500 other genes, about one-fifth of the human genome, as estimated by the Human Genome Project, says study co-author Michal K. Stachowiak.

In some respects, it’s like a boss gene,” says Stachowiak, PhD, professor in the Department of Pathology and Anatomical Sciences in the Jacobs School of Medicine and Biomedical Sciences at UB. “By controlling FGFR1, one can theoretically prevent widespread gene dysregulations in schizophrenia or in breast cancer and other types of cancer.”

The work — spearheaded by UB researchers Josep M. Jornet, Michal K. Stachowiak, Yongho Bae and Ewa K. Stachowiak — was reported in the June edition of the Proceedings of the Institute of Electrical and Electronics Engineers.

Source: http://www.buffalo.edu/

Tiny 4-Inch Wafer Holds One Million NanoRobots

Researchers have harnessed the latest nanofabrication techniques to create bug-shaped robots that are wirelessly powered, able to walk, able to survive harsh environments and tiny enough to be injected through an ordinary hypodermic needle.

When I was a kid, I remember looking in a microscope, and seeing all this crazy stuff going on. Now we’re building stuff that’s active at that size. We don’t just have to watch this world. You can actually play in it,” said Marc Miskin, who developed the nanofabrication techniques with his colleagues professors Itai Cohen and Paul McEuen and researcher Alejandro Cortese at Cornell University while Miskin was a postdoc in the laboratory for atomic and solid state physics there. In January, he became an assistant professor of electrical and systems engineering at the University of Pennsylvania.

Miskin will present his microscopic robot research on this week at the American Physical Society March Meeting in Boston. He will also participate in a press conference describing the work. Information for logging on to watch and ask questions remotely is included at the end of this news release.

Over the course of the past several years, Miskin and research colleagues developed a multistep nanofabrication technique that turns a 4-inch specialized silicon wafer into a million microscopic robots in just weeks. Each 70 micron long (about the width of a very thin human hair), the robots’ bodies are formed from a superthin rectangular skeleton of glass topped with a thin layer of silicon into which the researchers etch its electronics control components and either two or four silicon solar cells — the rudimentary equivalent of a brain and organs.

Robots are built massively in parallel using nanofabrication technology: each wafer holds 1 million machines

The really high-level explanation of how we make them is we’re taking technology developed by the semiconductor industry and using it to make tiny robots,” said Miskin.

Each of a robot’s four legs is formed from a bilayer of platinum and titanium (or alternately, graphene). The platinum is applied using atomic layer deposition. “It’s like painting with atoms,” said Miskin. The platinum-titanium layer is then cut into each robot’s four 100-atom-thick legs. “The legs are super strong,” he said. “Each robot carries a body that’s 1,000 times thicker and weighs roughly 8,000 times more than each leg.”

The researchers shine a laser on one of a robot’s solar cells to power it. This causes the platinum in the leg to expand, while the titanium remains rigid in turn, causing the limb to bend. The robot’s gait is generated because each solar cell causes the alternate contraction or relaxing of the front or back legs. The researchers first saw a robot’s leg move several days before Christmas 2017. “The leg just twitched a bit,” recalled Miskin. “But it was the first proof of concept — this is going to work!

Teams at Cornell and Pennsylvania are now at work on smart versions of the robots with on-board sensors, clocks and controllers. The current laser power source would limit the robot’s control to a fingernail-width into tissue. So Miskin is thinking about new energy sources, including ultrasound and magnetic fields, that would enable these robots to make incredible journeys in the human body for missions such as drug delivery or mapping the brain.

We found out you can inject them using a syringe and they survive — they’re still intact and functional — which is pretty cool,” he said.

Source: https://eurekalert.org/