Changing Vaccines’ Architecture Doubles the Number of T Cells, the Tumour Killers
February 2, 2023
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Posted by admin
A new way to significantly increase the potency of almost any vaccine has been developed by researchers from the International Institute for Nanotechnology (IIN) at Northwestern University.
The scientists used chemistry and nanotechnology to change the structural location of adjuvants and antigens on and within a nanoscale vaccine, greatly increasing vaccine performance. The antigen targets the immune system, and the adjuvant is a stimulator that increases the effectiveness of the antigen.
“The work shows that vaccine structure and not just the components is a critical factor in determining vaccine efficacy,” said lead investigator Chad A. Mirkin, director of the IIN. “Where and how we position the antigens and adjuvant within a single architecture markedly changes how the immune system recognizes and processes it."
This new heightened emphasis on structure has the potential to improve the effectiveness of conventional cancer vaccines, which historically have not worked well, Mirkin said.
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Categories: Uncategorized
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Tags: adjuvant, antigen-, colon cancer, IIN, International Institute for Nanotechnology, melanoma, nanoscale vaccine, nanotechnology, Northwestern University, papillomavirus-induced cervical cancer, prostate cancer, SNAs, spherical nucleic acids, T-cells, triple negative breast cancer, tumour, vaccine, vaccines' architecture
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