mRNA Are Super Potent Molecules, Fast And Efficient Against Coronavirus

CureVac AG, a clinical stage biopharmaceutical company pioneering mRNA-based drugs for vaccines and therapeutics, confirmed today that internal efforts are focused on the development of a coronavirus vaccine with the goal to reach, help and to protect people and patients worldwide. Based on its inherent mode of action, CureVac sees mRNA as one of the most potent molecules to provide fast and efficient solutions in outbreak scenarios, such like the Coronavirus. With inhouse expertise of over two decades and the company’s deep scientific understanding CureVac is leveraging its potent vaccine platform to focus on developing a potent, efficacious and safe and fast to produce vaccine against Covid-19.

CureVac recently announced successful vaccination results in its Rabies program fully protecting humans with two doses of only 1 microgram (1 millionth of a gram). These results are encouraging when thinking of supplying populations and people worldwide in a pandemic scenario. The company also has long and strong manufacturing expertise for mRNA-based vaccines and therapeutics since 2006. At this time, CureVac is working on expanding its manufacturing capacities to be able to provide up to billions of doses for outbreak situations like Covid-19.

Nature has invented mechanisms to activate our immune system against infectious diseases. With our unique messenger RNA technology we mimic nature and give our body the information how to fight against the virus. The combination of mRNA science, disease understanding, formulation and production expertise make CureVac a unique player to fight against any infectious disease, no matter whether they are seasonal or pandemic,” commented Mariola Fotin-Mleczek, Chief Technology Officer of CureVac.

Source: https://www.curevac.com/

How To Deliver Drug Deep In The Brain

By learning how rabies virus travels in the brain, Anti-Parkinson’s drug can be delivered deep in the brain where currently the drugs are not able to reachRabies virus has the capability to trick the nervous system and cross the blood brain barrier. This trick could be used for drug design. Glycoprotein 29 present on the rabies virus is attached to a nanoparticle stuffed full of deferoxamine ( Anti-Parkinson’s medication) and injected into the brain to trick the brain.

Rabies virus may have some tricks to bypass the blood brain barrier, this trick can be used to treat disease that require drugs to effectively cross the blood brain barrier, finds a new study.

The researchers can now exploit rabies viruses machinery to deliver a Parkinson’s disease medication directly to the brain. Upon injection the nanoparticles grab excess iron and relieve symptoms. While the common cause of Parkinson’s disease is unknown, it has been proved that accumulation of iron in neurons is one of the commonest features of Parkinson’s disease.

Deferoxamine is a metal-grabbing compound and sop up the excess iron in patients. But a large quantity of this drug needs to reach the brain in order for them work.
To usher deferoxamine into the brain, the researchers Yan-Zhong Chang, Xin Lou, Guangjun Nie took advantage of a key part of the rabies virusGlycoprotein 29.
When they injected this iron-grabbing nanoparticles into mouse models of Parkinson’s disease, the iron levels dropped and this reduced brain damage caused by Parkinson’s disease.

The findings of this study is published in the ACS Nano journal.

Source: https://www.acs.org/