3D Printing Pills In 7 Seconds

Long lines at the pharmacy may soon be a thing of the past! Getting your hands on needed medication can be a lengthy process with multiple steps involving doctor’s visits, referrals, prescriptions, and trips to the pharmacy. Moreover, mass-manufactured medicines may treat only some of your symptoms, relying on a one size fits most approach.

A new method for manufacturing medicines could solve some of these problems in the future. Alvaro Goyanes from the Department of Pharmacology at the University of Santiago de Compostela, and colleagues, have used innovations in 3D printing to produce customized pharmaceuticals in seconds. Their findings have been published in the journal Additive Manufacturing.

There are multiple 3D printing technologies, each of which utilize a different method for turning raw materials into printed objects. Some start as a powder or filament which is manipulated into a finished product, while others use a container filled with printable liquid. This method is known as vat polymerization and typically involves interactions with light which transform liquid monomers into solid polymers. In nearly every instance, the printing happens one layer at a time, which can mean that printing even small objects requires a considerable investment of time. Scientists used a modified version of vat polymerization to drastically reduce the amount of time needed to print medications.

Normally, in 3D printing, what you’re doing is called additive manufacturing. Every time you create a layer it takes time because the printer moves, or something changes. We created a mirrored system with light coming from three directions. There are no layers, the reaction takes place all at the same time,” explained Goyanes.

Typically, vat polymerization printers have only one source of light at the bottom, and layers are created one at a time, but this new system creates the entire object all at once, at the point where the three light sources come together. The entire printing process takes as little as seven seconds.

To create pharmaceuticals, researchers mixed active drug compounds into the monomers while they are in their liquid state. Once the printing is complete, those compounds are trapped within the polymers. Importantly, multiple tablets can be printed at one time, reducing the print time per tablet.

Right now, we are printing three tablets at a time, but it’s possible to print more than that at the same time. The fastest we managed to print was seven seconds, so the time per tablet is only a couple of seconds,” Goyanes said.

It’s worth noting that the monomers they’re using to print their medicine tablets are not currently approved for pharmaceutical use and further research is needed to ensure there aren’t any unexpected reactions occurring during the printing process. If all goes well, volumetric 3D printers could be deployed to hospital settings or pharmacies to rapidly print medications on demand.

The teams true focus, however, is developing a process for individualized medications, customized to the patient. Because the process is nearly instant and creates tablets in numbers more suited for individual prescriptions, future doctors could mix compounds at will to produce medications suited to the individual. You could feasibly even create a single tablet which contains all of the prescriptions a particular patient needs in a single pill.

Source: https://www.syfy.com/

3D-Printed On-Demand Drugs

A pharmaceutical scientist at the University of Sussex has published a guide to 3D and 4D printing technology in the biomedical and pharmaceutical arenas. Dr Mohammed Maniruzzaman, a lecturer in Pharmaceutics and Drug Delivery, edited 3D and 4D Printing in Biomedical Applications: Process Engineering and Additive Manufacturing’. He also authored sections of the book, alongside an international panel of academic scholars and industry experts. The book, written for pharmaceutical chemists, medicinal chemists, biotechnologists and pharma engineers, covers the key aspects of the printing of medical and pharmaceutical products and the challenges and advances associated with their development. It explores the process optimization, innovation process, engineering and technology behind printed medicine and provides information on biomedical developments such as shape memory polymers, 4D bio-fabrications and bone printing.

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There are numerous potential applications of this emerging technology. In the future we predict doctors would be able to send a 3D prescription to a Pharmacy, via e-mail or a shared server, and the Pharmacists would then be able to print the required dosage via a 3D printer placed right at the dispensing counter- at the point of need, eliminating the need for paper-based prescriptions. Similarly, we are not far off from when patients would be able to print their own medication on demand by using their small printing unit right at the kitchen or bedside”, explains Dr Maniruzzaman.

Another example can be that a 3D printer or bio-printer placed right by the operation bed in the operation theatre can print the medical implants required for that patient lying on the bed just right at the point of care. The dimensions and geometry of the implants can be tailored specifically for that patient saving both time and cost for manufacturing. Above all, this would enhance the patient compliance significantly,” he adds.

3D printing has appeared as one of the most promising additive manufacturing techniques across many industries, now including the medical and pharmaceutical arenas. 4D printing is an emerging technology that, simply put, refers to a printed object that transforms over time. It is envisaged this technology will revolutionize biomedical developments.

Source: http://www.sussex.ac.uk/