A Forest-based Yard Im­proved the Im­mune Sys­tem of Day­care Chil­dren in Only a Month

Playing through the greenery and litter of a mini forest‘s undergrowth for just one month may be enough to change a child’s immune system, according to an experiment in Finland. When daycare workers rolled out a lawn, planted forest undergrowth (such as dwarf heather and blueberries), and allowed children to care for crops in planter boxes, the diversity of microbes in the guts and on the skin of young kids appeared healthier in a very short space of time.

Compared to other city kids who play in standard urban daycares with yards of pavement, tile and gravel, 3-, 4-, and 5-year-olds at these greened-up daycare centers in Finland showed increased T-cells and other important immune markers in their blood within 28 days.


We also found that the intestinal microbiota of children who received greenery was similar to the intestinal microbiota of children visiting the forest every day,” explained environmental scientist Marja Roslund from the University of Helsinki in 2020, when the research was published.

Prior research has shown early exposure to green space is somehow linked to a well-functioning immune system, but it’s still not clear whether that relationship is causal or not.

The experiment in Finland is the first to explicitly manipulate a child’s urban environment and then test for changes in their microbiome and, in turn, a child’s immune system.

Source: https://www2.helsinki.fi/

Mass Extinction

Algae and bacteria are normal parts of a healthy freshwater environment, but sometimes they can grow out of control and deplete the water of oxygen, creating ‘dead zones. This tends to happen with global warming, deforestation, and the rush of soil nutrients into waterways, which can feed microbes. All three of these factors are in play today, which is why we are probably seeing increases in toxic blooms already. Considering what’s happened in the past, that’s a disturbing sign.

According to soil, fossil, and geochemical data from the Sydney Basin, researchers think the spread of microbes in the wake of the Permian extinctionwas both a symptom of continental ecosystem collapse, and a cause of its delayed recovery.” Volcanic eruptions in the Permian first triggered an accelerated and sustained rise in greenhouse gas emissions. This caused higher global temperatures and sudden deforestation due to wildfires or drought.

Once the trees were gone, it wasn’t long before the structure of the soil began to erode, and its nutrients slipped into freshwater ecosystems. For more than three million years, Earth’s forests struggled to recover. The Sydney Basin was instead littered with lowland ecosystems that “were regularly inundated by stagnant, fresh/brackish waterbodies hosting thriving algal and bacterial populations“, the authors write. In turn, these persistent dead zones prevented the reestablishment of important carbon sinks, like peatlands, and slowed down climate and ecosystem recovery.

This major episode caused vast amounts of dust and sulfate aerosols to rise into the atmosphere, but compared to volcanic activity, the meteorite only caused a modest increase in atmospheric carbon dioxide and temperature, not a sustained one. As such, freshwater microbes only seemed to undergo a short-lived burst after the extinction event. Unfortunately, that’s very different from what occurred during the Permian extinction and what is happening today.

For instance, the researchers note that the “optimal temperature growth range” of these harmful algae in freshwater environments is 20-32 °C (68-89.6 °F). That range matches the estimated continental summer surface air temperatures for the region during the early Triassic. That range is what’s projected for mid-latitude continental summer surface air temperatures in 2100. Scientists are noticing other similarities, including an increase in forest fires and the subsequent destabilization of soils.

The other big parallel is that the increase in temperature at the end of the Permian coincided with massive increases in forest fires,” says geologist Chris Fielding, also from the University of Connecticut. “One of the things that destroyed whole ecosystems was fire, and we’re seeing that right now in places like California. One wonders what the longer-term consequences of events like that as they are becoming more and more widespread.

The good news is that this time many of the changes are in our control. The bad news is that whatever happens next is our own fault. “The end-Permian mass extinction event took four million years to recover from,” Fielding says. “That’s sobering.”

Source: https://www.nature.com/

How to Reverse Age-related Brain Deterioration

Research from APC Microbiome Ireland (APCSFI Research Centre at University College Cork (UCC) published in the journal Nature Aging introduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut.

As our population ages one of the key global challenges is to develop strategies to maintain healthy brain function. This ground-breaking research opens up a potentially new therapeutic avenues in the form of microbial-based interventions to slow down brain aging and associated cognitive problems. The work was carried out by researchers in the Brain-Gut-Microbiota lab in APC led by Prof John F. Cryan, Vice President for Research & Innovation, University College Cork as well as a Principal Investigator at APC Microbiome Ireland an SFI Research Centre, based in in University College Cork and Teagasc Moorepark.

There is a growing appreciation of the importance of the microbes in the gut on all aspects of physiology and medicine. In this latest mouse study the authors show that by transplanting microbes from young into old animals they could rejuvenate aspects of brain and immune function.

Prof John F. Cryan, says “Previous research published by the APC and other groups internationally has shown that the gut microbiome plays a key role in aging and the aging process. This new research is a potential game changer , as we have established that the microbiome can be harnessed to reverse age-related brain deterioration. We also see evidence of improved learning ability and cognitive function”.

Although very exciting Cryan cautions that “it is still early days and much more work is needed to see how these findings could be translated in humans”.

APC Director Prof Paul Ross stated that “This research of Prof. Cryan and colleagues further demonstrates the importance of the gut microbiome in many aspects of health, and particularly across the brain/gut axis where brain functioning can be positively influenced. The study opens up possibilities in the future to modulate gut microbiota as a therapeutic target to influence brain health”.

The study was led by co-first authors Dr Marcus Boehme along with PhD student Katherine E. Guzzetta, and Dr Thomaz Bastiaanssen.

Source: https://www.ucc.ie/

Bacteria trapped — and terminated — by graphene filter

Airborne bacteria may see what looks like a comfy shag carpet on which to settle. But it’s a trapRice University scientists have transformed their laser-induced graphene (LIG) into self-sterilizing filters that grab pathogens out of the air and kill them with small pulses of electricity. The flexible filter developed by the Rice lab of chemist James Tour may be of special interest to hospitalsAccording to the Centers for Disease Control and Prevention, patients have a 1-in-31 chance of acquiring a potentially antibiotic-resistant infection during hospitalization. The device described in the American Chemical Society journal ACS Nano captures bacteria, fungi, fungi, prions, endotoxins and other biological contaminants carried by droplets, aerosols and particulate matter. The filter then prevents the microbes and other contaminants from proliferating by periodically heating up to 350 degrees Celsius (662 degrees Fahrenheit), enough to obliterate pathogens and their toxic byproducts. The filter requires little power, and heats and cools within seconds.

LIG is a conductive foam of pure, atomically thin carbon sheets synthesized through heating the surface of a common polyimide sheet with an industrial laser cutter. The process discovered by Tour’s lab in 2014 has led to a range of applications for electronics, triboelectric nanogenerators, composites, electrocatalysis and even art. Like all pure graphene, the foam conducts electricity. When electrified, Joule heating raises the filter’s temperature above 300 C, enough to not only kill trapped pathogens but also to decompose toxic byproducts that can feed new microorganisms and activate the human immune system. The researchers suggested a single, custom-fit LIG filter could be efficient enough to replace the two filter beds currently required by federal standards for hospital ventilation systems.

Seen in an electron microscope image, micron-scale sheets of graphene created at Rice University form a two-layer air filter that traps pathogens and then kills them with a modest burst of electricity

So many patients become infected by bacteria and their metabolic products, which for example can result in sepsis while in the hospital,” Tour said. “We need more methods to combat the airborne transfer of not just bacteria but also their downstream products, which can cause severe reactions among patients.

“Some of these products, like endotoxins, need to be exposed to temperatures of 300 degrees Celsius in order to deactivate them,” a purpose served by the LIG filter, he added. “This could significantly lessen the transfer of bacteria-generated molecules between patients, and thereby lower the ultimate costs of patient stays and lessen sickness and death from these pathogens.”

The lab tested LIG filters with a commercial vacuum filtration system, pulling air through at a rate of 10 liters per minute for 90 hours, and found that Joule heating successfully sanitized the filters of all pathogens and byproducts. Incubating used filters for an additional 130 hours revealed no subsequent bacterial growth on the heated units, unlike control LIG filters that had not been heated.

Bacteria culturing experiments performed on a membrane downstream from the LIG filter indicated that bacteria are unable to permeate the LIG filter,” said Rice sophomore John Li, co-lead author of the paper with postdoctoral researcher Michael Stanford. Stanford noted the sterilization feature “may reduce the frequency with which LIG filters would need to be replaced in comparison to traditional filters.” Tour suggested LIG air filters could also find their way into commercial aircraft.

Source: https://news.rice.edu/