How to Reverse Age-related Brain Deterioration

Research from APC Microbiome Ireland (APCSFI Research Centre at University College Cork (UCC) published in the journal Nature Aging introduces a novel approach to reverse aspects of aging-related deterioration in the brain and cognitive function via the microbes in the gut.

As our population ages one of the key global challenges is to develop strategies to maintain healthy brain function. This ground-breaking research opens up a potentially new therapeutic avenues in the form of microbial-based interventions to slow down brain aging and associated cognitive problems. The work was carried out by researchers in the Brain-Gut-Microbiota lab in APC led by Prof John F. Cryan, Vice President for Research & Innovation, University College Cork as well as a Principal Investigator at APC Microbiome Ireland an SFI Research Centre, based in in University College Cork and Teagasc Moorepark.

There is a growing appreciation of the importance of the microbes in the gut on all aspects of physiology and medicine. In this latest mouse study the authors show that by transplanting microbes from young into old animals they could rejuvenate aspects of brain and immune function.

Prof John F. Cryan, says “Previous research published by the APC and other groups internationally has shown that the gut microbiome plays a key role in aging and the aging process. This new research is a potential game changer , as we have established that the microbiome can be harnessed to reverse age-related brain deterioration. We also see evidence of improved learning ability and cognitive function”.

Although very exciting Cryan cautions that “it is still early days and much more work is needed to see how these findings could be translated in humans”.

APC Director Prof Paul Ross stated that “This research of Prof. Cryan and colleagues further demonstrates the importance of the gut microbiome in many aspects of health, and particularly across the brain/gut axis where brain functioning can be positively influenced. The study opens up possibilities in the future to modulate gut microbiota as a therapeutic target to influence brain health”.

The study was led by co-first authors Dr Marcus Boehme along with PhD student Katherine E. Guzzetta, and Dr Thomaz Bastiaanssen.

Source: https://www.ucc.ie/

How To Strengthen Your Immune System

There’s another reason to celebrate the gut microbiome—a healthy gut might actually be able to save lives. According to scientists at the Lawson Health Research Institute, all it takes to strengthen your immune system is to improve your gut health, a process that we know is as easy as increasing your ingestion of probiotics and dietary fiber. How’s that for functional food?

These Lawson Health Research Institute scientists are implementing a preliminary study that would discover whether a fecal transplant of a healthy microbiome can help patients with melanoma become more receptive to immunotherapy treatments. During immunotherapy treatments, patients take certain drugs to stimulate their immune systems in order to attack tumors in their bodies. A fecal transplant, according to these researchers, would make their immune systems more receptive to the drugs and, in turn, could help more people successfully fight their cancer.

We know that some people’s immune systems don’t respond well, and it seems to be associated with the microbes within your gut,” Michael Silverman, M.D., a Lawson associate scientist, said in a video filmed by the research institute. “The goal is to give people healthy microbes to replenish the microbes in their gut so that their immune system responds optimally, and they’re able to control the tumor.”

Source: https://www.mindbodygreen.com/