Future space food could be made from astronaut breath

The future of space food could be as simple—and weird—as a protein shake made with astronaut breath or a burger made from fungus. For decades, astronauts have relied mostly on pre-packaged food, or the occasional grown lettuce, during their forays off our planet. With missions beyond Earth orbit in sight, a NASA-led competition is hoping to change all that and usher in a new era of sustainable space food.

Currently the pre-packaged food that we use on the International Space Station has a shelf life of a year and a half,” says Ralph Fritsche, senior project manager for space crop production at NASA’s Kennedy Space Center in Florida. “We don’t have a food system at this point in time that can really handle a mission to Mars,” he says. Longer-duration missions to the moon would present a similar problem.

And while it may be some time before humans ever reach Mars, the moon is very much on the agenda. Next year, NASA plans to send four astronauts flying around the moon as part of its Artemis program, in the first crewed moon mission since Apollo 17 in 1972. The goal is to get humans back on the surface later this decade, at first for days at a time but eventually for weeks, months, or even longer.

To solve the problem of feeding astronauts on long-duration missions, NASA started the Deep Space Food Challenge in January 2021, asking companies to propose novel ways to develop sustainable foods for future missions. About 200 companies entered—a field that was whittled down to 11 teams in January 2023 as part of phase 2, with eight US teams each given $20,000 in funding and three additional international teams also recognized. A handful of winners to be announced in April 2024 following more detailed tests of their proposals. “Phase 2 was kind of a kitchen-level demonstration,” says Angela Herblet at NASA’s Marshall Space Flight Center in Alabama, the project manager for the challenge. “Phase 3 is going to challenge the teams to scale their technologies.”

Entrants had to show systems that could operate for three years and feed a crew of four on a prospective space mission. The proposals did not need to supply a crew’s entire diet, but they did need to create a variety of nutritious foods for the astronauts. Earlier this year, judges then visited each company to “see the food and really analyze it,” says Herblet.

One company took a particularly unusual approach to the task. Air Company, based in New York and one of the eight US-based finalists, designed a system that could use the carbon dioxide expelled by astronauts in space to produce alcohol, which could then be used to grow edible food. The company already develops alcohols from CO2 for plane fuel and perfume.

It’s making food out of air,” says Stafford Sheehan, cofounder and chief technology officer of Air Company. “It sounds like magic, but when you see it actually operating, it’s much more simple. We’re taking CO2, combining it with water and electricity, and making proteins.”

The process produces alcohol that can then be fed to yeast, producing “something that’s edible,” says Sheehan. For the competition they created essentially a protein shake, described as being similar to one made from seitan, a vegan meat substitute. “It actually tastes pretty good,” says Sheehan. For astronauts in space, the system would ferment continuously to supply food. “Whenever you feel like you want a space protein shake, you make one from this yeast that’s growing,” says Sheehan.

Interstellar Lab in Florida, another of the US-based phase 2 finalists, had a different approach. Its system, called NUCLEUS, is a modular set of small toaster-size capsules. Each is self-contained, with its own humidity, temperature, and watering system. That would allow different vegetables—or even insects such as black soldier flies, often cited as a promising protein source—to be cultivated so that astronauts can easily grow their own food in space.

Source: https://www.aircompany.com/
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https://www.technologyreview.com/

Priming The Immune System To Attack Cancer

Immunotherapies, such as checkpoint inhibitor drugs, have made worlds of difference for the treatment of cancer. Most clinicians and scientists understand these drugs to act on what’s known as the adaptive immune system, the T cells and B cells that respond to specific threats to the body.

New research from an international team co-led by George Hajishengallis of the University of Pennsylvania School of Dental Medicine suggests that the innate immune system, which responds more generally to bodily invaders, may be an important yet overlooked component of immunotherapy’s success.

Their work, published in the journal Cell, found that “training” the innate immune system with β-glucan, a compound derived from fungus, inspired the production of innate immune cells, specifically neutrophils, that were primed to prevent or attack tumors in an animal model.

The focus in immunotherapy is placed on adaptive immunity, like checkpoint inhibitors inhibit the interaction between cancer cells and T cells,” says Hajishengallis, a co-senior author on the work. “The innate immune cells, or myeloid cells, have not been considered so important. Yet our work suggests the myeloid cells can play a critical role in regulating tumor behavior.”

The current study builds on earlier work published in Cell by Hajishengallis and a multi-institutional team of collaborators, which showed that trained immunity, elicited through exposure to exposure to the fungus-derived compound β-glucan, could improve immune recovery after chemotherapy in a mouse model.

In that previous study, the researchers also showed that the “memory” of the innate immune system was held within the bone marrow, in hematopoetic stem cells that serve as precursors of myeloid cells, such as neutrophils, monocytes, and macrophages.

Source: https://penntoday.upenn.edu/