Extension of the Life of Immune System Means Live Longer

A new mechanism that slows down and may even prevent the natural ageing of immune cells – one of the ninehallmarks of ageing’* – has been identified by an international team led by UCL scientists.

Published in Nature Cell Biology, researchers say the discovery in-vitro (cells) and validated in mice was ‘unexpected’ and believe harnessing the mechanism could extend the life of the immune system, allowing people to live healthier and longer, and would also have clinical utility for diseases such as cancer and dementia.

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The DNA Drug Revolution

Doctors have been treating the symptoms of most diseases, and not the source, for centuries. They have cut out tumors, unclogged arteries, injected insulin and soothed fevers—and have been unable to touch the biological code within cells that tells them to grow malignantly, pass along abnormal nerve signals, take in too much or too little energy, and swell with inflammation. The code is the DNA molecule in each cell that tells it what to do and when, and it triggers dreaded diseases when it goes wrong. The molecule, and its messengers, had remained tucked away, beyond the reach of almost all drugs, unfixable when broken. But as this special report explains, that is no longer the case.

Things began to change after the DNA sequence for the entire human genome was laid out early in this century, and within the past several years the ability to synthesize and custom-design shorter sequences has shown scientists that the best substance for reaching DNA is, well, DNA. Fabricating new genes to replace badly working versions, or to “silence” them, has produced 14 approved DNA-related drugs. And the latest research indicates that such therapies can be even more effective if scientists depart from the basic linear strands and instead make DNA spheres, which have enhanced abilities to enter cells. DNA analysis has also yielded new targets, showing that although newborn babies in the U.S. are typically screened for between 30 and 60 genetic conditions right now, it is possible to and nearly 1,000 genes linked to childhood diseases that could be new treatment points.

But that same science has also created troubling issues: some of the gene tests for infants can raise false alarms, for instance, and not every child with a disease-associated gene ends up getting that disease. Research has also revealed unfair bias in DNA targets. Most of the data about those sequences comes from studies of white people and has missed gene variants that cause disease in nonwhitesinequality in research that will produce inequality in health if it isn’t fixed. Geneticists are starting projects designed to improve this diversity level. DNA in medicine has great power, and that power should be used for the many, not the few.

Source: https://www.scientificamerican.com/