Smart Contact Lenses for Cancer Diagnostics and Screening

Scientists from the Terasaki Institute for Biomedical Innovation (TIBI) have developed a contact lens that can capture and detect exosomes, nanometer-sized vesicles found in bodily secretions which have the potential for being diagnostic cancer biomarkers. The lens was designed with microchambers bound to antibodies that can capture exosomes found in tears. This antibody- conjugated signaling microchamber contact lens (ABSM-CL) can be stained for detection with nanoparticle-tagged specific antibodies for selective visualization. This offers a potential platform for cancer pre-screening and a supportive diagnostic tool that is easy, rapid, sensitive, cost-effective, and non-invasive.

Exosomes are formed within most cells and secreted into many bodily fluids, such as plasma, saliva, urine, and tears. Once thought to be the dumping grounds for unwanted materials from their cells of origin, it is now known that exosomes can transport different biomolecules between cells. It has also been shown that there is a wealth of surface proteins on exosomes – some that are common to all exosomes and others that are increased in response to cancer, viral infections, or injury. In addition, exosomes derived from tumors can strongly influence tumor regulation, progression, and metastasis.

Because of these capabilities, there has been much interest in using exosomes for cancer diagnosis and prognosis/treatment prediction. However, this has been hampered by the difficulty in isolating exosomes in sufficient quantity and purity for this purpose. Current methods involve tedious and time-consuming ultracentrifuge and density gradients, lasting at least ten hours to complete.


Contact Lens Zooms On Your Command

It is absolutely the stuff of science fiction: a contact lens that zooms on your command. But scientists at the University of California San Diego have gone ahead and made it a reality. They’ve created a contact lens, controlled by eye movements, that can zoom in if you blink twice.

How is this possible? In the simplest of terms, the scientists measured the electrooculographic signals generated when eyes make specific movements (up, down, left, right, blink, double blink) and created a soft biomimetic lens that responds directly to those electric impulses. The lens created was able to change its focal length depending on the signals generated.

Therefore the lens could literally zoom in the blink of an eye. Incredibly, the lens works regardless of whether the user can see or not. It’s not about the sight, it’s about the electricity produced by specific movements.

Why create this? Why the hell not. The researchers believe this innovation could be used in “visual prostheses, adjustable glasses, and remotely operated robotics in the future,” but I’m waiting for them to turn up on CSI Miami. Could you imagine the crimes Ice-T could solve wearing these things?