First Cultivated Meat Approved By The FDA

A major milestone is currently underway in the realm of cultivated meat. Food scientists have spent decades of research and development crafting new meat to tackle the increasing demand for this produce, reduce environmental degradation, and support animal welfare (via CNN). Now, one company is swiftly on its way to producing some of the country's first cultured protein. Following its first pre-market consultation, the FDA has evaluated the safety of cultivated chicken created by Upside Foods and confirmed that there are no further questions at this time.

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How to Regrow Amputated Limbs

Scientists in the US have successfully regrown the lost legs of a group of frogs in a significant advance for regenerative medicine. The research is an important step to one day helping people who have experienced the loss of a limb and opens the door to the potential use of a similar treatment on humans in the future.

The African clawed frog used in the research does not have the ability to naturally regenerate a limb and was treated with a five-drug cocktail over 24 hours. That brief treatment set in motion an 18-month period of regrowth that restored a functional leg.

It’s exciting to see that the drugs we selected were helping to create an almost complete limb,” said Nirosha Murugan, research affiliate at the Allen Discovery Centre at Tufts and first author of the paper outlining the experiment. “The fact that it required only a brief exposure to the drugs to set in motion a months-long regeneration process suggests that frogs and perhaps other animals may have dormant regenerative capabilities that can be triggered into action”.

The researchers used a group of 115 adult African clawed frogs. They amputated a limb of each frog, then split them up into three groups; one group received the full treatment, one group received no treatment to act as a control and one group received partial treatment. Scientists triggered the regenerative process in the frogs by enclosing the wound for 24 hours in a silicone cap, which they call a BioDome, containing a silk protein gel loaded with the five-drug cocktail. The drugs each had a different purpose, including tamping down inflammation and encouraging the new growth of nerve fibres, blood vessels, and muscle. The bioreactor helped to stop the natural tendency to close off the stump, and instead encourage the regenerative process.

Source: https://www.euronews.com/

The Science Of BioPrinting a Human Heart

A company called Biolife4D has developed the technology to print human cardiac tissue by collecting blood cells from a patient and converting these cells to a type of stem cell called Induced Pluripotent Stem (iPS) cells. The technology could eventually be used to create thousands of much-needed hearts for transplantation.

What we’re working on is literally bioprinting a human heart viable for transplantation out of a patient’s own cells, so that we’re not only addressing the problem with the lack of [organ] supply, but by bioengineering the heart out of their own cells, we’re eliminating the rejection,Biolife4D CEO Steven Morris said during an appearance on Digital Trends Live, referring to the body’s impulse to reject a transplanted organ.

It starts with a patient’s own cells and ends with a 3D bioprinted heart that’s a precise fit and genetic match. The BIOLIFE4D bioprinted organ replacement process begins with a magnetic resonance imaging (MRI) procedure used to create a detailed three-dimensional image of a patient’s heart. Using this image, a computer software program will construct a digital model of a new heart for the patient, matching the shape and size of the original.

A “bio-ink” is created using the specialized heart cells combined with nutrients and other materials that will help the cells survive the bioprinting processHearts created through the BIOLIFE4D bioprinting process start with a patient’s own cells. Doctors safely take cells from the patient via a blood sample, and leveraging recent stem cell research breakthroughs, BIOLIFE4D plans to reprogram those blood cells and convert them to create specialized heart cells.

Bioprinting is done with a 3D bioprinter that is fed the dimensions obtained from the MRI. After printing, the heart is then matured in a bioreactor, conditioned to make it stronger and readied for patient transplant.

Source: https://biolife4d.com/