How to Deliver Chemo Straight to the Brain to Kill Cancer

The blood-brain barrier is an important aspect of the brain’s blood vessels that prevents poisons, viruses, and bacteria in blood from infiltrating the brain—but it inadvertently blocks most therapeutic substances. Nanoparticles, focused ultrasound, clever chemistry, and other innovative ideas are being tried to overcome the barrier and deliver treatments to the brain. Now, neurosurgeons at Columbia University and NewYork-Presbyterian are taking a more direct approach: a fully implantable pump that continuously delivers chemo through a tube inserted directly into the brain.

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