Anti-inflammatory Molecules Decline in the Aging Brain
Aging involves complicated plot twists and a large cast of characters: inflammation, stress, metabolism changes, and many others.
Now, a team of Salk Institute and UC San Diego scientists reveal another factor implicated in the aging process—a class of lipids called SGDGs (3-sulfogalactosyl diacylglycerols) that decline in the brain with age and may have anti-inflammatory effects.
The research, published in Nature Chemical Biology, helps unravel the molecular basis of brain aging, reveals new mechanisms underlying age-related neurological diseases, and offers future opportunities for therapeutic intervention.
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