New Molecule Kills The Flu Virus

Influenza is one of the most widespread viral diseases and constitutes a major public health problem. For some, it means spending a week in bed; for others, it could lead to hospitalization or, in the most severe cases, death. Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL)’s Supramolecular Nano-Materials and Interfaces Laboratory (SuNMIL) within the School of Engineering, working in association with the team headed by Caroline Tapparel, a professor at the University of Geneva’s Department of Microbiology and Molecular Medicine, have synthesized a compound that can kill the virus that causes influenza. Their discovery paves the way to effective drug therapies against the seasonal disease.

With the flu virus, the risk of a pandemic is high,” says Francesco Stellacci, the EPFL professor who heads SuNMIL. “Scientists have to update the vaccine every year because the strain mutates, and sometimes the vaccine turns out to be less effective. So it would be good to also have antivirals that could limit the effects of large-scale infection.

“Antiviral drugs already exist, and Tamiflu is the most well-known. But it has one major drawback – it has to be taken within 36 hours of infection or it loses its efficacy completely. And with influenza, symptoms generally start appearing 24 hours after infection. “By the time patients seek medical treatment, it’s often too late for Tamiflu,” explained Stellacci. “In addition, for antivirals to really work, they have to be virucidal – that is, they have to irreversibly inhibit viral infectivity. But today that’s not the case.

The research has been published in Advanced Science.