Tag Archives: deferoxamine

How To Deliver Drug Deep In The Brain

By learning how rabies virus travels in the brain, Anti-Parkinson’s drug can be delivered deep in the brain where currently the drugs are not able to reachRabies virus has the capability to trick the nervous system and cross the blood brain barrier. This trick could be used for drug design. Glycoprotein 29 present on the rabies virus is attached to a nanoparticle stuffed full of deferoxamine ( Anti-Parkinson’s medication) and injected into the brain to trick the brain.

Rabies virus may have some tricks to bypass the blood brain barrier, this trick can be used to treat disease that require drugs to effectively cross the blood brain barrier, finds a new study.

The researchers can now exploit rabies viruses machinery to deliver a Parkinson’s disease medication directly to the brain. Upon injection the nanoparticles grab excess iron and relieve symptoms. While the common cause of Parkinson’s disease is unknown, it has been proved that accumulation of iron in neurons is one of the commonest features of Parkinson’s disease.

Deferoxamine is a metal-grabbing compound and sop up the excess iron in patients. But a large quantity of this drug needs to reach the brain in order for them work.
To usher deferoxamine into the brain, the researchers Yan-Zhong Chang, Xin Lou, Guangjun Nie took advantage of a key part of the rabies virusGlycoprotein 29.
When they injected this iron-grabbing nanoparticles into mouse models of Parkinson’s disease, the iron levels dropped and this reduced brain damage caused by Parkinson’s disease.

The findings of this study is published in the ACS Nano journal.

Source: https://www.acs.org/