One Injection Reduces Obesity In 4 Weeks

An injection has helped reduce body weight and glucose levels in patients with diabetes and obesity in four weeks. The findings came from a small study in which patients lost on average 4.4kg and the treatment led to substantial improvements to their blood glucose, with some patients’ reducing to near-normal levels.Obesity is a common problem in the UK and it is estimated that one in four adults are obese. One of the most common types of weight loss surgery is a procedure known as gastric bypass surgery, which can be very effective in keeping excess weight off and improving blood sugar levels in diabetics.  However, some patients decide against surgery and the procedure can cause complications such as abdominal pain, chronic nausea, vomiting and debilitating low blood sugar levels.

Previous research by Imperial College London suggested that one of the reasons why gastric bypass surgery works so well is because three specific hormones originating from the bowels are released in higher levels. This hormone combination, called ‘GOP’ for short, reduces appetite, causes weight loss and improves the body’s ability to use the sugar absorbed from eating. Researchers wanted to see if infusing patients with the GOP hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin and peptide YY, to mimic the high levels seen after surgery, could aid weight loss and reduce high glucose levelsFifteen patients were given the GOP treatment for four weeks using a pump that slowly injects the GOP mixture under the skin for 12 hours a day, beginning one hour before breakfast and disconnecting after their last meal of the day. Patients also received dietetic advice on healthy eating and weight loss from a dietician.

Obesity and type 2 diabetes can lead to very serious and potentially life-threatening conditions such as cancer, stroke and heart disease. There is a real need to find new medicines so we can improve and save the lives of many patients, said Tricia Tan, Professor of Practice (Metabolic Medicine & Endocrinology) at Imperial College London and lead author of the study. “Although this is a small study our new combination hormone treatment is promising and has shown significant improvements in patients’ health in only four weeks.  Compared to other methods the treatment is non-invasive and reduced glucose levels to near-normal levels in our patients”, she adds.

Source: https://www.imperial.ac.uk/