Daily Archives: May 1, 2019

Hypothalamic Stem Cells May Reverse The Human Ageing Process

A study published in the Nature Journal by Dongsheng Cai, Albert Einstein College of Medicine, New York, talks about how stem cells, that determines how fast aging occurs in the body, can help reverse the human ageing process. Stem cells reside in Hypothalamus, a pea-sized part of the brain that contains a bundle of neurons. It is responsible for a wide array of growth, development, digestion, reproduction, and metabolism related processes in the body. As the human body starts to age, these neural stem cells in the body begins to deteriorate and accelerates the human ageing process. So, if you stop these stem cells from wearing away, you can possibly stop the human body from ageing.

The lab tests were conducted on mice, where it was observed that as the mice grew 10 months or older, the stem cells begin to deplete (earlier than the usual time for stem cells to deteriorate in mice). By the time, these mice turn two years and older, the stem cells start to disappear, causing death. However, to prove their hypothesis that stem cells deterioration truly accelerates the ageing process, scientists ‘artificially disrupted’ the stem cells in middle-aged mice, and observed that it significantly grew their rate of ageing.

Once the hypothesis that stem cells depletion leads to accelerated ageing was proved, scientists further injected the hypothalamic stem cells into the brains of older and middle-aged mice, where a sudden decrease in their ageing process was observed. This happens because the hypothalamic stem cells release molecules called microRNAs (miRNAs) which play an important role in regulation of gene expression. These miRNAs (which are bundled inside tiny particles called exosomes) released by the stem cells were then further injected into the cerebrospinal fluid of mice.

After this experiment, the ageing process significantly slowed down, in terms of tissue analysis and behavioral analysis where different changes in animals’ muscle endurance, coordination, social behavior and cognitive ability also showed signs of anti-ageing. Scientists are now looking into exploring the study further and analyze other factors related to microRNAs that might be responsible for the anti-ageing miracle!

Source: https://www.nature.com/
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