DNA Folds Into A Smart Nanocapsule For Drug Delivery

Researchers from University of Jyväskylä and Aalto University in Finland have developed a customized DNA nanostructure that can perform a predefined task in human body-like conditions. To do so, the team built a capsule-like carrier that opens and closes according to the pH level of the surrounding solution. The nanocapsule can be loaded—or packed—with a variety of cargo, closed for delivery and opened again through a subtle pH increase.

DNA folds into a smart nanocapsule for drug delivery
The pH-responsive DNA origami nanocapsule (blue) loaded with an enzyme (yellow color, high pH). 

The function of the DNA nanocapsule is based on pH-responsive DNA residues.To make this happen, the team designed a capsule-like DNA origami structure functionalized with pH-responsive DNA strands. Such dynamic DNA nanodesigns are often controlled by the simple hydrogen-bonding of two complementary DNA sequences. Here, one half of the capsule was equipped with specific double-stranded DNA domains that could further form a DNA triple helix — in other words a helical structure comprised of three, not just two DNA molecules — by attaching to a suitable single-stranded DNA in the other half.

Source: https://www.jyu.fi/